Understanding how lung blood vessel cells contribute to lung scarring
Role of lung endothelial cells during fibrotic lung remodeling
This study is looking at how certain cells in the lungs change when someone has interstitial lung diseases like idiopathic pulmonary fibrosis (IPF), with the hope of finding new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10870173 on NIH RePORTER |
What this research studies
This research investigates the role of lung endothelial cells in the development of interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF). It focuses on how these cells change during lung injury and contribute to the scarring process. By studying both human and mouse lung cells, the researchers aim to identify key factors that regulate the transformation of normal endothelial cells into those that promote fibrosis. The ultimate goal is to uncover the molecular mechanisms behind this process, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis or other interstitial lung diseases.
Not a fit: Patients with acute lung injuries or those not diagnosed with interstitial lung diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce lung scarring in patients with interstitial lung diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of endothelial cells in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Kalin, Tanya — University of Arizona
- Study coordinator: Kalin, Tanya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.