Understanding how lung blood vessel cells change during early development
Developmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell Resolution
This study is looking at how certain cells in the lungs change as they grow, especially in premature babies, to help find better treatments for lung problems like bronchopulmonary dysplasia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11222414 on NIH RePORTER |
What this research studies
This research investigates the changes in pulmonary endothelial cells, which are crucial for lung development, particularly during the postnatal period when the lungs are growing and maturing. By using advanced techniques like single cell transcriptomics, the study aims to identify the different types of endothelial cells and the molecular mechanisms that regulate their growth and transition to a resting state. This understanding could help in developing targeted therapies for conditions related to abnormal blood vessel growth in the lungs, such as bronchopulmonary dysplasia, a common issue in premature infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants or those at risk of developing lung complications related to abnormal angiogenesis.
Not a fit: Patients with fully developed lungs or those not experiencing issues related to lung vascular development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for lung diseases associated with abnormal blood vessel development in infants.
How similar studies have performed: Other research has shown promise in understanding endothelial cell behavior in various contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Alvira, Cristina Maria — University of California, San Francisco
- Study coordinator: Alvira, Cristina Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.