Understanding how lung bacteria affect inflammation in COPD for people with HIV
Official title: Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual
Funded at Makerere University College of Health Sciences · NIH-10872354 · Data updated 2026-11-12
This study is looking at how the bacteria in the lungs and inflammation are connected in people with COPD who also have HIV, to see how HIV might affect lung health over time, and it involves patients providing samples to help us learn more about this relationship.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Makerere University College of Health Sciences NIH-funded |
| Lab location | 1 site (Kampala, Uganda) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $100,000 |
| NIH project number | 3R21TW012354-02S2 |
| Project ID | NIH-10872354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also have been diagnosed with COPD, particularly those residing in Sub-Saharan Africa.
✕Less likely to help
Patients who do not have COPD or are not living with HIV may not receive any benefit from this research.
What this research studies
This research investigates the relationship between the lung microbiome and inflammation in individuals with Chronic Obstructive Pulmonary Disease (COPD) who are also living with HIV. It focuses on how chronic HIV infection may lead to changes in the immune response, particularly in the lungs, which could worsen lung function over time. By examining the immune system and the bacteria present in the lungs, the study aims to uncover mechanisms that contribute to lung health decline in this population. Patients may undergo assessments and provide samples to help researchers understand these interactions better.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for COPD in HIV-infected individuals, potentially enhancing their quality of life.
How similar studies have gone: While the specific focus on the lung microbiome in this context may be novel, there is existing research indicating that understanding immune responses in COPD and HIV can lead to significant insights.
Where this research is happening
-
Makerere University College of Health Sciences
Kampala, Uganda Active
Researchers
- Principal investigator: Kayongo, Alex — Makerere University College of Health Sciences
- Study coordinator: Kayongo, Alex
Related research
Other NIH-funded projects on the same topics.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD
A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.
-
Next-Generation Wearable AI for Precision COPD Risk and Care
A patient-centered project uses a smart wearable and AI to predict COPD flare-ups and support doctors in making better care decisions.
-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
-
Easier, local pulmonary rehab and social support for people with COPD in low-resource clinics
This project compares a 10-week community pulmonary rehabilitation program alone, the same program plus help with social needs, and usual care for people with moderate-to-severe COPD to see which helps people stick with rehab and feel better.
-
Improving COPD outcomes with real-world data
A doctor-scientist at a major university is using real-world information from COPD patients to understand which treatments work best, how safe they are, and whether people stick to their inhaler plans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.