Understanding how lung bacteria affect inflammation in COPD for people with HIV
Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual
This study is looking at how the bacteria in the lungs and inflammation are connected in people with COPD who also have HIV, to see how HIV might affect lung health over time, and it involves patients providing samples to help us learn more about this relationship.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Makerere University College of Health Sciences NIH-funded |
| Lab location | 1 site (Kampala, Uganda) |
| Project ID | NIH-10872354 on NIH RePORTER |
What this research studies
This research investigates the relationship between the lung microbiome and inflammation in individuals with Chronic Obstructive Pulmonary Disease (COPD) who are also living with HIV. It focuses on how chronic HIV infection may lead to changes in the immune response, particularly in the lungs, which could worsen lung function over time. By examining the immune system and the bacteria present in the lungs, the study aims to uncover mechanisms that contribute to lung health decline in this population. Patients may undergo assessments and provide samples to help researchers understand these interactions better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have been diagnosed with COPD, particularly those residing in Sub-Saharan Africa.
Not a fit: Patients who do not have COPD or are not living with HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for COPD in HIV-infected individuals, potentially enhancing their quality of life.
How similar studies have performed: While the specific focus on the lung microbiome in this context may be novel, there is existing research indicating that understanding immune responses in COPD and HIV can lead to significant insights.
Where this research is happening
Kampala, Uganda
- Makerere University College of Health Sciences — Kampala, Uganda (Active)
Researchers
- Principal investigator: Kayongo, Alex — Makerere University College of Health Sciences
- Study coordinator: Kayongo, Alex
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.