Understanding how lung bacteria affect inflammation in COPD for people with HIV
Official title: Investigating the role of altered lung microbiome in fueling Th17 mediated airway inflammation in COPD among HIV-infected individual
Funded at Makerere University College of Health Sciences · NIH-10791969 · Data updated 2026-11-12
This study is looking at how the germs in the lungs might affect inflammation in people with COPD who are living with HIV, and it wants to hear from folks in rural Uganda about their thoughts and worries about a lung procedure called bronchoscopy, so we can make sure everyone feels comfortable and informed if they choose to participate in future research.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Makerere University College of Health Sciences NIH-funded |
| Lab location | 1 site (Kampala, Uganda) |
| Project start | September 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $199,955 |
| NIH project number | 3R21TW012354-02S1 |
| Project ID | NIH-10791969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-infected individuals over 21 years old who have been diagnosed with COPD.
✕Less likely to help
Patients who are not HIV-infected or do not have COPD may not benefit from this research.
What this research studies
This research investigates the relationship between the lung microbiome and inflammation in the airways of HIV-infected individuals suffering from Chronic Obstructive Pulmonary Disease (COPD). It aims to gather insights from potential participants in rural Uganda about their perceptions and concerns regarding research bronchoscopy, a procedure that allows access to lung samples. The study will also develop a community engagement plan to enhance participation and ethical conduct in future research. By addressing participant needs and ethical considerations, the research seeks to improve the consenting process for bronchoscopy studies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of airway inflammation in HIV-infected patients with COPD.
How similar studies have gone: While the specific approach of integrating community engagement in bronchoscopy studies is novel, similar research has shown success in understanding patient perspectives in other medical procedures.
Where this research is happening
-
Makerere University College of Health Sciences
Kampala, Uganda Active
Researchers
- Principal investigator: Kayongo, Alex — Makerere University College of Health Sciences
- Study coordinator: Kayongo, Alex
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.