Understanding how Lunatic Fringe affects Notch signaling in pancreatic cancer
Official title: Dissecting roles of Lunatic Fringe-dependent Notch signaling in pancreatic cancer
Funded at University of Mississippi Med Ctr · NIH-11075790 · Data updated 2026-11-12
This study is looking at how a protein called Lunatic Fringe affects cell development in the pancreas, which could help us understand how pancreatic cancer starts and grows, with the hope of finding better ways to detect and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $354,563 |
| NIH project number | 5R01CA276347-02 |
| Project ID | NIH-11075790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with pancreatic cancer or those at high risk due to genetic factors.
✕Less likely to help
Patients with other types of cancer or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of a specific protein called Lunatic Fringe in the Notch signaling pathway, which is crucial for cell development and differentiation in the pancreas. By using mouse models that mimic human pancreatic cancer, the study aims to uncover how changes in these signaling pathways contribute to the initiation and progression of pancreatic cancer. The research focuses on understanding the cellular origins of pancreatic cancer and how specific genetic mutations influence tumor development. This could lead to new strategies for early detection and treatment of pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early detection and targeted therapies for pancreatic cancer, potentially increasing survival rates.
How similar studies have gone: Previous research has shown promising results in understanding the role of signaling pathways in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Xu, Keli — University of Mississippi Med Ctr
- Study coordinator: Xu, Keli
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.