Understanding how LSD1 affects oral cancer and exploring new treatments
Mechanism of LSD1 Function and Its Therapeutic Application for Progressive Oral Malignancy
This study is looking at how a protein called LSD1 affects the growth of oral cancer and whether blocking this protein can help stop the cancer from getting worse, with the hope of finding better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012339 on NIH RePORTER |
What this research studies
This research investigates the role of LSD1, a protein that modifies histones, in the progression of oral squamous cell carcinoma (OSCC). The study aims to understand how LSD1 contributes to tumor growth and how inhibiting this protein can prevent the transition from dysplasia to invasive cancer. By using animal models and applying LSD1 inhibitors, researchers hope to reduce tumor progression and improve treatment outcomes. The findings could lead to new therapeutic strategies for patients with oral malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral squamous cell carcinoma or those at high risk of developing this condition.
Not a fit: Patients with non-cancerous oral conditions or those with advanced-stage oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that slow down or prevent the progression of oral cancer.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting LSD1 in cancer treatment, indicating potential for success in this study.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Bais, Manish — Boston University Medical Campus
- Study coordinator: Bais, Manish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.