Understanding how LSD1 affects breast cancer spread
Mechanism of LSD1 in breast cancer metastasis suppression
This study is looking at how a protein called LSD1 might help stop breast cancer from spreading to other parts of the body, which could lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10988268 on NIH RePORTER |
What this research studies
This research investigates the role of LSD1, an epigenetic regulator, in the suppression of breast cancer metastasis. By examining how LSD1 interacts with specific transcription factors and influences cell behavior, the study aims to uncover mechanisms that could prevent the spread of breast cancer to other parts of the body. The approach includes analyzing genetic and epigenetic changes in breast cancer cells and using animal models to observe the effects of manipulating LSD1 activity. Patients may benefit from insights that could lead to new treatments targeting metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-breast cancer types or those whose cancer has already metastasized extensively may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively prevent breast cancer from spreading.
How similar studies have performed: Other research has shown promising results in targeting epigenetic mechanisms in cancer, suggesting that this approach may yield significant insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Li, Zhe — Brigham and Women's Hospital
- Study coordinator: Li, Zhe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.