Understanding how LRRK2 affects Parkinson's disease
Molecular Regulation of LRRK2 in Parkinson's Disease
This study is looking at how a protein called LRRK2 affects the nerve cell damage in Parkinson's disease, with the goal of finding new ways to help improve treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10764930 on NIH RePORTER |
What this research studies
This research investigates the role of the LRRK2 protein in Parkinson's disease, focusing on how its regulation impacts the degeneration of neurons that cause the disease's symptoms. The study aims to explore both the GTPase and kinase activities of LRRK2, which are crucial for its function. By examining the mechanisms that control LRRK2, researchers hope to identify new therapeutic targets that could lead to better treatments for patients with Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those with genetic mutations in the LRRK2 gene.
Not a fit: Patients with Parkinson's disease who do not have LRRK2 mutations may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or halt the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in targeting LRRK2 for therapeutic development, indicating that this approach has potential for success.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Xiong, Yulan — University of Connecticut Sch of Med/dnt
- Study coordinator: Xiong, Yulan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.