Understanding how LRP6 affects bone mass and development
Pathogenesis of LRP6 High Bone Mass
This study is looking at how a protein called LRP6 affects bone health in people with high bone mass, especially those with certain genetic changes, to see how these changes impact bone density and structure.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10445060 on NIH RePORTER |
What this research studies
This research investigates the role of LRP6, a protein involved in bone formation, particularly in individuals with high bone mass conditions. By studying families with specific genetic mutations in LRP6, the research aims to uncover how these mutations influence bone density and structure. The approach includes genetic analysis and clinical assessments to understand the relationship between LRP6 mutations and bone health. Patients may undergo tests to evaluate their bone density and related features.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with high bone mass conditions, particularly those with genetic mutations affecting LRP6.
Not a fit: Patients without high bone mass conditions or those not carrying relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into bone health and potential treatments for conditions related to abnormal bone density.
How similar studies have performed: Previous research has shown promising results in understanding bone density through genetic studies, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mumm, Steven R — Washington University
- Study coordinator: Mumm, Steven R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.