Understanding how LRP5 affects immune cells in cancer treatment
A novel signaling mechanism for LRP5
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10851885
This study is looking at how a protein called LRP5 affects the way certain immune cells work to fight cancer, with the hope of finding new ways to make cancer treatments more effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10851885 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the LRP5 protein in regulating natural killer (NK) cell activities and tumor immunity. By exploring how LRP5 influences immune responses, the study aims to uncover new mechanisms that could enhance cancer immunotherapy. The researchers will conduct both laboratory experiments and animal studies to analyze the effects of LRP5 on NK cell function and its potential as a target for improving cancer treatments. The findings could lead to innovative strategies for boosting the immune system's ability to fight cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that may benefit from enhanced immune responses, particularly those undergoing immunotherapy.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not influenced by immune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new cancer treatments that enhance the immune system's ability to target and destroy tumors.
How similar studies have performed: Other research has shown promising results in enhancing cancer treatment through immune modulation, suggesting that this approach may also yield significant findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, DIANQING — YALE UNIVERSITY
- Study coordinator: WU, DIANQING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Treatment