Understanding how LPGAT1 affects fat metabolism
Official title: The Function of Mammalian LPGAT1
Funded at New York University School of Medicine · NIH-11010750 · Data updated 2026-11-12
This study is looking at how a specific enzyme called LPGAT1 affects fat processing in the liver, which could help us understand and find new treatments for conditions like obesity and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 10, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $464,930 |
| NIH project number | 5R01HL166418-03 |
| Project ID | NIH-11010750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity, metabolic syndrome, or atherosclerosis.
✕Less likely to help
Patients with metabolic disorders unrelated to fat metabolism may not receive benefit from this research.
What this research studies
This research investigates the role of the enzyme LPGAT1 in the metabolism of fats, particularly focusing on how it influences the composition of fatty acids in important phospholipids. By examining the mechanisms of phospholipid remodeling and lipid synthesis in liver cells, the study aims to uncover how abnormalities in these processes contribute to conditions like obesity and atherosclerosis. Patients may benefit from insights gained into fat metabolism that could lead to new treatments for metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing obesity and cardiovascular diseases.
How similar studies have gone: Other research has shown promising results in understanding lipid metabolism, making this approach both relevant and potentially impactful.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Schlame, Michael — New York University School of Medicine
- Study coordinator: Schlame, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.