Understanding how low oxygen levels affect pancreatic cancer spread
Elucidation of hypoxia-induced metastatic reprogramming through the regulation of KDM8 function in pancreatic cancer
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11005316
This study is looking at how low oxygen levels in pancreatic tumors affect cancer cells, especially a gene called KDM8, to find new ways to treat pancreatic cancer and help patients feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11005316 on ClinicalTrials.gov |
What this research studies
This research investigates how low oxygen levels in the tumor environment influence the behavior of pancreatic cancer cells, particularly focusing on a gene called KDM8. By studying how KDM8 affects cancer cell differentiation and metastasis, the researchers aim to uncover new vulnerabilities in pancreatic cancer that could lead to better treatment options. The approach involves analyzing gene expression changes in cancer cells under different oxygen conditions, using advanced techniques like chromatin immunoprecipitation. The ultimate goal is to identify potential therapeutic targets that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma, particularly those with advanced or metastatic disease.
Not a fit: Patients with early-stage pancreatic cancer or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the aggressive forms of pancreatic cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in targeting metabolic and environmental factors in cancer treatment, suggesting that this approach could also yield significant insights.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIOU, SHIN-HENG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: CHIOU, SHIN-HENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, cancer metastasis, cancer microenvironment, Cancers