Understanding how low oxygen levels affect lymphatic function in lymphedema
Official title: A Critical Role for Hypoxia-Inducible Factors in Lymphedema
Funded at Palo Alto Veterans Instit for Research · NIH-10886751 · Data updated 2026-11-12
This study is looking at how low oxygen levels in the body might affect a protein that helps keep your lymphatic system working well, with the goal of finding new ways to help people with lymphedema feel better and reduce swelling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $524,950 |
| NIH project number | 5R01HL150583-04 |
| Project ID | NIH-10886751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lymphedema, particularly those experiencing significant swelling and discomfort.
✕Less likely to help
Patients who do not have lymphedema or those with other unrelated chronic conditions may not benefit from this research.
What this research studies
This research investigates the role of hypoxia-inducible factors in the progression of lymphedema, a condition characterized by chronic swelling due to lymphatic drainage issues. The study focuses on how inflammation affects the expression of a specific protein, HIF-2α, in lymphatic endothelial cells, which is crucial for maintaining proper lymphatic function. By exploring the mechanisms behind this reduction, the research aims to identify potential therapeutic targets that could improve lymphatic drainage and alleviate symptoms for patients suffering from lymphedema.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lymphatic function and reduce swelling in lymphedema patients.
How similar studies have gone: Previous studies have shown promising results in using anti-inflammatory therapies to improve lymphatic function, suggesting that this approach may be effective.
Where this research is happening
-
Palo Alto Veterans Instit for Research
Palo Alto, United States Active
Researchers
- Principal investigator: Jiang, Xinguo — Palo Alto Veterans Instit for Research
- Study coordinator: Jiang, Xinguo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.