Understanding how low oxygen levels affect gene expression in lung diseases
Official title: A novel mechanism regulating genome-wide mRNA expression in hypoxic lung disease
Funded at University of South Alabama · NIH-11028810 · Data updated 2026-11-12
This study is looking at how low oxygen levels in the body affect genes related to lung diseases, with the hope of finding new ways to understand and treat these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $605,678 |
| NIH project number | 1R01HL177087-01 |
| Project ID | NIH-11028810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from lung diseases exacerbated by low oxygen levels.
✕Less likely to help
Patients with lung diseases not related to hypoxia may not benefit from this research.
What this research studies
This research investigates how low oxygen levels, or hypoxia, influence the expression of many genes involved in lung diseases. It focuses on the role of reactive oxygen species in activating specific transcription factors that regulate gene activity. By exploring the genomic response to hypoxia, the study aims to uncover new mechanisms that could lead to better understanding and treatment of lung conditions. The approach includes examining how oxidative changes in DNA may serve as signals for gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung diseases associated with hypoxia.
How similar studies have gone: Other research has shown promising results in understanding gene regulation under hypoxic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Gillespie, Mark N — University of South Alabama
- Study coordinator: Gillespie, Mark N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.