Understanding how low oxygen levels affect gene expression in lung diseases
A novel mechanism regulating genome-wide mRNA expression in hypoxic lung disease
This study is looking at how low oxygen levels in the body affect genes related to lung diseases, with the hope of finding new ways to understand and treat these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project ID | NIH-11028810 on NIH RePORTER |
What this research studies
This research investigates how low oxygen levels, or hypoxia, influence the expression of many genes involved in lung diseases. It focuses on the role of reactive oxygen species in activating specific transcription factors that regulate gene activity. By exploring the genomic response to hypoxia, the study aims to uncover new mechanisms that could lead to better understanding and treatment of lung conditions. The approach includes examining how oxidative changes in DNA may serve as signals for gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from lung diseases exacerbated by low oxygen levels.
Not a fit: Patients with lung diseases not related to hypoxia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating lung diseases associated with hypoxia.
How similar studies have performed: Other research has shown promising results in understanding gene regulation under hypoxic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Mobile, United States
- University of South Alabama — Mobile, United States (Active)
Researchers
- Principal investigator: Gillespie, Mark N — University of South Alabama
- Study coordinator: Gillespie, Mark N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.