Understanding how low oxygen levels affect blood vessel function in the lungs
Official title: Oxidant Signaling in Pulmonary Hypertension
Funded at University of New Mexico Health Scis Ctr · NIH-10881993 · Data updated 2026-11-12
This study is looking at how low oxygen levels can cause high blood pressure in the lungs, which can be a problem for people with chronic lung diseases or those living at high altitudes, and it aims to find new ways to help treat this condition by understanding how low oxygen affects cholesterol in lung cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $574,429 |
| NIH project number | 5R01HL169945-02 |
| Project ID | NIH-10881993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with chronic obstructive pulmonary disease (COPD), sleep apnea, or those living in high-altitude areas.
✕Less likely to help
Patients with isolated pulmonary hypertension not related to chronic hypoxia or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates how chronic low oxygen levels can lead to pulmonary hypertension, a condition where blood vessels in the lungs become constricted. The study focuses on the role of oxidant signaling mechanisms in pulmonary arterial smooth muscle cells, which may contribute to increased blood vessel resistance and heart strain. By examining how low oxygen affects cholesterol levels in these cells, the researchers aim to uncover new pathways that could be targeted for treatment. Patients with chronic lung diseases or those living at high altitudes may find this research particularly relevant.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary hypertension, improving the quality of life for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of pulmonary hypertension related to chronic hypoxia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Resta, Thomas C — University of New Mexico Health Scis Ctr
- Study coordinator: Resta, Thomas C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.