Understanding how low oxygen levels affect blood stem cells
Official title: Regulation of hematopoietic stem cells under low oxygen tension
Funded at Indiana University Indianapolis · NIH-11040034 · Data updated 2026-11-12
This study is looking at how low oxygen levels affect blood stem cells, which are important for making all kinds of blood cells, to find ways to help improve treatments for blood disorders like anemia or leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $792,498 |
| NIH project number | 1R01HL177669-01 |
| Project ID | NIH-11040034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hematopoietic diseases who may require stem cell transplantation or gene therapy.
✕Less likely to help
Patients with non-hematopoietic conditions or those not requiring blood cell therapies may not benefit from this research.
What this research studies
This research investigates how low oxygen conditions influence hematopoietic stem cells (HSCs), which are crucial for producing all types of blood cells. By studying these cells in a low oxygen environment, the researchers aim to uncover mechanisms that enhance their growth and functionality. The approach involves examining the signaling pathways and metabolic changes in HSCs when exposed to hypoxia, which could lead to improved methods for blood cell transplantation and gene therapy. Patients may benefit from advancements in treatments for blood disorders through better understanding and manipulation of these stem cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with blood disorders by improving blood stem cell therapies.
How similar studies have gone: Previous studies have shown promising results in enhancing stem cell functionality under low oxygen conditions, indicating potential for success in this area.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Kapur, Reuben — Indiana University Indianapolis
- Study coordinator: Kapur, Reuben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.