Understanding how low oxygen during pregnancy affects the placenta and baby's brain
Molecular and bioenergetic dynamics of in utero chronic hypoxia on placenta and brain
This research explores how a lack of oxygen in the womb impacts the placenta and a baby's developing brain, which can lead to neurodevelopmental challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11164616 on NIH RePORTER |
What this research studies
When the placenta isn't working well due to conditions like high blood pressure or diabetes, a baby might not get enough oxygen while in the womb. This lack of oxygen can disrupt the vital connection between the placenta and the baby's brain, potentially affecting brain development. Our team uses advanced imaging and molecular techniques in models to understand how this chronic low oxygen changes the brain's energy use and gene activity. By studying these complex interactions, we aim to uncover the root causes of brain injury and neurodevelopmental disorders that can arise from these conditions.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biological mechanisms of in utero hypoxia, and therefore does not directly involve patient participation at this stage.
Not a fit: Patients who have not experienced chronic low oxygen during pregnancy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect babies from brain injuries and neurodevelopmental disorders caused by low oxygen during pregnancy.
How similar studies have performed: This project builds on existing expertise in prenatal brain injury modeling and introduces novel 4D in utero imaging technology to gain a comprehensive understanding.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Cristancho, Ana — Children's Hosp of Philadelphia
- Study coordinator: Cristancho, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.