Understanding how low oxygen and temperature affect living organisms
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
This study is looking at how low oxygen and cold temperatures affect tiny worms, fish, and brain cells, to find out how some living things manage to survive these tough conditions, which could help improve treatments for strokes and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11001533 on NIH RePORTER |
What this research studies
This research investigates how low oxygen levels (hypoxia) and low temperatures (hypothermia) impact cellular processes and behaviors in various organisms. By studying genetically modified C. elegans and Mangrove Killifish, as well as mammalian neural stem cells, the research aims to uncover the genetic and cellular mechanisms that allow some organisms to tolerate these extreme conditions. The findings could lead to better treatments for ischemic disorders like stroke and heart attacks, particularly through the use of therapeutic hypothermia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of ischemic disorders, such as those with cardiovascular diseases or a history of stroke.
Not a fit: Patients with conditions unrelated to hypoxia or hypothermia, or those not at risk for ischemic events, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from conditions like stroke and heart attacks by enhancing our understanding of how to protect brain and heart tissues during low oxygen and temperature events.
How similar studies have performed: Previous research has shown promising results in understanding hypoxia and hypothermia responses, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Ma, Dengke — University of California, San Francisco
- Study coordinator: Ma, Dengke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.