Understanding how low oxygen affects brain cell movement in newborns
Official title: Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury
Funded at University of California, San Francisco · NIH-10997031 · Data updated 2026-11-12
This study is looking at how low oxygen levels during birth can affect the movement of important brain cells in newborns, using piglets to help us understand how this might lead to future learning and development challenges for babies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,720 |
| NIH project number | 1F31NS139663-01 |
| Project ID | NIH-10997031 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who have experienced hypoxic injury during birth.
✕Less likely to help
Patients who have not experienced any form of neonatal hypoxic injury are unlikely to benefit from this research.
What this research studies
This research investigates how neonatal hypoxic injury, a condition caused by low oxygen levels during birth, affects the migration of inhibitory interneurons in the developing brain. By using a piglet model, the study aims to uncover the mechanisms behind the misdirection of these important brain cells, which could lead to long-term neurological issues. The researchers will employ computational methods to analyze changes in signaling pathways that may be disrupted by hypoxia, focusing on specific receptors involved in cell migration. This work is crucial for understanding the impact of early brain injuries on infant development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating neurological disabilities in infants affected by hypoxic injury.
How similar studies have gone: Previous research has shown promising results in understanding brain cell migration and the effects of hypoxia, but this specific approach using a piglet model is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Poddar, Aunoy — University of California, San Francisco
- Study coordinator: Poddar, Aunoy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.