Understanding how low leptin levels affect the body's response to low blood sugar
Evaluating the role of hypoleptinemia in impaired counterregulatory responses to hypoglycemia
This study is looking at how low levels of a hormone called leptin might make it harder for people with diabetes to handle low blood sugar, especially after things like exercise or drinking alcohol, and it hopes to find new ways to help manage blood sugar better and keep you safe from low blood sugar episodes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-11030233 on NIH RePORTER |
What this research studies
This research investigates how low levels of leptin, a hormone that helps regulate energy balance, may impair the body's ability to respond to low blood sugar in individuals with diabetes. The study aims to identify the mechanisms behind this impairment, particularly in relation to factors like recurrent low blood sugar episodes, exercise, and alcohol consumption. By developing pre-clinical data, the research seeks to find new drug targets that could help prevent hypoglycemic complications, ultimately improving treatment options for patients. The findings could lead to more effective strategies for managing blood sugar levels and reducing the risks associated with hypoglycemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who experience recurrent episodes of hypoglycemia.
Not a fit: Patients who do not have diabetes or do not experience hypoglycemic episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of hypoglycemia in people with diabetes.
How similar studies have performed: Previous research has indicated potential success in understanding hormonal influences on blood sugar regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
Baton Rouge, United States
- Lsu Pennington Biomedical Research Ctr — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Mcdougal, David Harry — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Mcdougal, David Harry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.