Understanding how loss of TDP-43 affects brain activity and connections in dementia.
Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRD
This study is looking at how a protein called TDP-43 affects brain activity and connections in the early stages of Alzheimer's and similar diseases, with the goal of finding new ways to help people who are experiencing memory loss and cognitive decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project ID | NIH-10563569 on NIH RePORTER |
What this research studies
This research investigates the role of TAR DNA-binding protein 43 (TDP-43) in the early changes in brain activity and circuitry that lead to neuron loss in Alzheimer's Disease and related dementias. By examining how the loss of TDP-43 contributes to cognitive decline and brain atrophy, the study aims to uncover potential therapeutic targets for these conditions. The researchers will utilize a multidisciplinary approach, including advanced techniques to analyze neural activity and RNA splicing related to calcium channels. This work is crucial for developing new treatment strategies for patients suffering from these debilitating diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or Alzheimer's Disease Related Dementias, particularly those exhibiting TDP-43 pathology.
Not a fit: Patients with cognitive impairments not linked to TDP-43 pathology or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent cognitive decline in patients with Alzheimer's Disease and related dementias.
How similar studies have performed: Previous research has shown that targeting TDP-43 pathology can lead to significant insights in neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
Laramie, United States
- University of Wyoming — Laramie, United States (Active)
Researchers
- Principal investigator: Li, Yun — University of Wyoming
- Study coordinator: Li, Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.