Understanding how loss of myelin leads to increased brain activity and seizures
Demyelination is coupled to neuronal hyperexcitability leading to seizures
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-10984894
This study is looking at how damage to the protective covering of nerve fibers in people with multiple sclerosis might make their brains more likely to have seizures, and it aims to find out what happens in the brain during this process to help improve treatments for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-10984894 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between demyelination, a process where the protective covering of nerve fibers is damaged, and increased neuronal excitability that can lead to seizures, particularly in patients with multiple sclerosis (MS). The researchers aim to identify the cellular and molecular changes that occur during demyelination, using a mouse model to monitor brain activity through advanced techniques like electroencephalography (EEG). By understanding these mechanisms, the study hopes to shed light on why MS patients are more prone to epilepsy and how these processes can be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing seizures or are at risk of developing them.
Not a fit: Patients without multiple sclerosis or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of seizures in patients with multiple sclerosis.
How similar studies have performed: Previous research has shown a correlation between demyelination and increased seizure activity, but this study aims to explore these mechanisms in greater detail, making it a novel approach.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TIWARI-WOODRUFF, SEEMA K — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: TIWARI-WOODRUFF, SEEMA K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.