Understanding how loss of myelin leads to increased brain activity and seizures
Demyelination is coupled to neuronal hyperexcitability leading to seizures
This study is looking at how damage to nerve coverings in people with multiple sclerosis might lead to seizures, and it’s testing whether a special diet can help understand this connection better using mice to see how their brains react.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10773018 on NIH RePORTER |
What this research studies
This research investigates the connection between demyelination, a process where the protective covering of nerve fibers is damaged, and increased neuronal excitability that can lead to seizures, particularly in patients with multiple sclerosis (MS). The researchers aim to uncover the cellular and molecular changes that occur during demyelination, using a mouse model to monitor brain activity and identify when and where seizures begin. By analyzing the effects of a specific diet on these mice, they hope to gain insights into the mechanisms that contribute to epilepsy in MS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing seizures or are at risk of developing them.
Not a fit: Patients without multiple sclerosis or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of seizures in patients with multiple sclerosis.
How similar studies have performed: Previous research has shown that understanding the mechanisms of demyelination can lead to significant advancements in treating related neurological conditions, suggesting potential success for this approach.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Tiwari-Woodruff, Seema K — University of California Riverside
- Study coordinator: Tiwari-Woodruff, Seema K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.