Understanding how loss of DNA repair affects colon cancer stem cells
The selective advantage of mismatch repair loss in colonic stem cells
This study is looking at Lynch syndrome, a genetic condition that raises the risk of certain cancers, especially colorectal cancer, to understand how some stem cells in the colon might survive better when there's a lot of DNA damage, which could help explain how cancer develops and lead to new treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11042815 on NIH RePORTER |
What this research studies
This research investigates Lynch syndrome, a hereditary condition that increases the risk of various cancers, particularly colorectal cancer. It focuses on how the loss of DNA mismatch repair (MMR) function in colonic stem cells may provide these cells with a survival advantage in environments with high DNA damage. By utilizing advanced human colonic organoid models, the research aims to explore the dynamics of these stem cells and their potential role in cancer development. Patients may gain insights into the mechanisms of their condition and potential future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Lynch syndrome or those with a family history of colorectal cancer.
Not a fit: Patients without Lynch syndrome or those who do not have a genetic predisposition to colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Lynch syndrome and related cancers.
How similar studies have performed: Previous research has shown promising results in understanding cancer mechanisms through similar approaches, particularly using organoid models.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Heinen, Christopher D. — University of Connecticut Sch of Med/dnt
- Study coordinator: Heinen, Christopher D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.