Understanding how loss of a key molecule in mitochondria affects brain injury in newborns.
The Role of FMN Loss by Mitochondrial Complex I in Neonatal Hypoxic-Ischemic Brain Injury
This study is looking at how a lack of oxygen can hurt newborns' brains and is exploring ways to help, like using certain vitamins and cooling techniques, to find better treatments for conditions such as cerebral palsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10800746 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind brain injuries caused by lack of oxygen in newborns, specifically focusing on how the loss of flavin mononucleotide (FMN) in mitochondrial complex I contributes to brain damage. By studying the effects of oxidative stress on energy metabolism in the brain, the researchers aim to identify potential therapeutic strategies, such as using riboflavin and hypothermia, to prevent or reduce injury. The study involves preclinical approaches to better understand and mitigate the damage caused by hypoxic-ischemic conditions. Patients may benefit from insights gained that could lead to improved treatments for conditions like cerebral palsy.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns or infants who have experienced hypoxic-ischemic events.
Not a fit: Patients who have not experienced hypoxic-ischemic injury or those outside the neonatal age group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce brain injury in newborns suffering from oxygen deprivation.
How similar studies have performed: Other research has shown promise in similar approaches targeting mitochondrial function and oxidative stress in brain injury, suggesting potential for success in this area.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Galkin, Alexander — Weill Medical Coll of Cornell Univ
- Study coordinator: Galkin, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.