Understanding how long-term signals affect brain circuits that control eating
Official title: Investigating how long-term signals modulate brainstem satiation circuits
Funded at University of California, San Francisco · NIH-10876927 · Data updated 2026-11-12
This study looks at how certain brain cells help control how much we eat by balancing long-term energy needs with short-term signals from our stomach, and it’s designed for anyone interested in understanding eating habits and finding ways to prevent overeating or not eating enough.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $44,892 |
| NIH project number | 5F31DK137586-02 |
| Project ID | NIH-10876927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals over 21 years old who are interested in understanding the biological mechanisms of eating and weight regulation.
✕Less likely to help
Patients with neurological disorders affecting brain function may not benefit from this research.
What this research studies
This research investigates how the brainstem regulates meal size by integrating long-term energy signals with short-term feedback from the digestive system. It focuses on specific brain cells that play a crucial role in meal termination and how they respond to various signals during eating. By studying these interactions in awake mice, the research aims to uncover the mechanisms that influence food intake and prevent overeating or underfeeding. This could lead to a better understanding of eating behaviors and potential interventions for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing eating behaviors and preventing obesity.
How similar studies have gone: Previous research has shown success in understanding short-term feeding signals, but this investigation into long-term energy balance modulation is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ly, Truong — University of California, San Francisco
- Study coordinator: Ly, Truong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.