Understanding how long-term cannabis use affects aging in older adults

Comprehensive portrait of long-term cannabis users: Are they ready for old age?

NIH-funded research Duke University · NIH-10764226

This study is looking at how long-term cannabis use affects the health and memory of older adults who have used it regularly for many years, especially as they get older and face risks like Alzheimer's disease.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionDuke University NIH-funded
Lab location1 site (Durham, United States)
Project IDNIH-10764226 on NIH RePORTER

What this research studies

This research investigates the effects of long-term cannabis use on the aging process in older adults, particularly focusing on those who have used cannabis regularly for decades. It aims to assess their cognitive and biological health as they enter later life, specifically looking at risks for conditions like Alzheimer's disease. By analyzing data from a unique cohort study, the research will explore whether these individuals maintain their cognitive reserve and overall health as they age. Participants will be evaluated through in-depth interviews and clinical assessments to understand their health status and aging trajectory.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 50 and above who have been regular cannabis users for at least 30 years.

Not a fit: Patients who do not use cannabis or have only used it sporadically may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide insights into how long-term cannabis use impacts health and aging, potentially guiding better health strategies for older adults.

How similar studies have performed: While there is ongoing research into cannabis use and health, this specific focus on long-term users in the context of aging is relatively novel.

Where this research is happening

Durham, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.