Understanding how long noncoding RNAs help balance gene expression between male and female mammals
Elucidating the molecular basis of lncRNA evolution for mammalian dosage compensation
This study is exploring how certain RNA molecules help balance gene activity between males and females by turning off one of the X chromosomes in females, which could lead to new insights for understanding diseases related to sex chromosomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10873976 on NIH RePORTER |
What this research studies
This research investigates the role of long noncoding RNAs (lncRNAs) in the process of dosage compensation in mammals, which is crucial for balancing gene expression between males and females. The study focuses on how these lncRNAs contribute to the silencing of one of the X chromosomes in females, a process that has evolved to prevent gene dosage imbalances. By utilizing advanced CRISPR techniques, the researchers aim to elucidate the evolutionary history and functional significance of these lncRNAs in gene regulation. Patients may benefit from insights gained into genetic mechanisms that could influence various diseases linked to sex chromosomes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders linked to X chromosome abnormalities.
Not a fit: Patients with conditions unrelated to sex chromosome dosage or those not affected by genetic factors may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic regulation that may improve treatments for diseases associated with sex chromosomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Sun, Sha — University of California-Irvine
- Study coordinator: Sun, Sha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.