Understanding how long noncoding RNAs affect immune cell function
High throughput functional characterization of lncRNAs in macrophage biology
This study is looking at how certain molecules called long noncoding RNAs help immune cells called macrophages work, especially when the body is dealing with inflammation, like in sepsis, to better understand how they can protect us during illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10890610 on NIH RePORTER |
What this research studies
This research investigates the role of long noncoding RNAs (lncRNAs) in macrophages, which are crucial immune cells. By utilizing advanced sequencing technologies, the study aims to identify and characterize the gene networks that regulate macrophage functions and their responses to inflammation. The researchers will create specialized cell lines to screen for lncRNAs and their protein partners, ultimately developing mouse models to validate their findings in living organisms. This innovative approach seeks to uncover the biological significance of lncRNAs in immune responses, particularly during conditions like sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve macrophage dysfunction or inflammatory responses, such as sepsis or autoimmune diseases.
Not a fit: Patients with conditions unrelated to immune response or those not involving macrophage biology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for enhancing immune responses in patients with inflammatory diseases.
How similar studies have performed: While the role of lncRNAs is a relatively novel area of investigation, preliminary studies have shown promise in understanding their functions in other biological contexts.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Carpenter, Susan — University of California Santa Cruz
- Study coordinator: Carpenter, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.