Understanding how long noncoding RNAs affect immune cell behavior
High throughput functional characterization of lncRNAs in macrophage biology
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA SANTA CRUZ · NIH-11140086
This study is looking at how certain molecules in immune cells called macrophages help them respond to inflammation and other challenges, which could lead to new ways to understand and improve immune health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA CRUZ (nih funded) |
| Locations | 1 site (SANTA CRUZ, UNITED STATES) |
| Trial ID | NIH-11140086 on ClinicalTrials.gov |
What this research studies
This research investigates the role of long noncoding RNAs (lncRNAs) in macrophages, which are crucial immune cells. By using advanced sequencing technologies, the team aims to identify and characterize the gene networks that regulate macrophage functions, particularly in response to inflammation and immune challenges. The study will involve creating specialized cell lines and mouse models to explore how these lncRNAs interact with proteins and influence immune responses. This innovative approach seeks to uncover new insights into the biological processes that govern immune cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune dysfunction or inflammatory diseases.
Not a fit: Patients with non-inflammatory conditions or those not affected by immune system issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory diseases and improving immune responses.
How similar studies have performed: Previous research has shown promise in understanding the roles of lncRNAs in various biological processes, indicating that this approach could yield significant insights.
Where this research is happening
SANTA CRUZ, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA CRUZ — SANTA CRUZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARPENTER, SUSAN — UNIVERSITY OF CALIFORNIA SANTA CRUZ
- Study coordinator: CARPENTER, SUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene