Understanding how long non-coding RNAs affect uterine fibroids
Mechanism of Long Non-coding RNAs Action in leiomyoma
This study is looking at how certain molecules called long non-coding RNAs might play a role in the growth of fibroids, which are non-cancerous tumors that many women experience, to help find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project ID | NIH-10662468 on NIH RePORTER |
What this research studies
This research investigates the role of long non-coding RNAs (lncRNAs) in the development of uterine leiomyomas, commonly known as fibroids, which are benign tumors affecting many women of reproductive age. The study focuses on how specific lncRNAs interact with microRNAs (miRNAs) to influence gene expression related to inflammation, fibrosis, and cell cycle regulation in these tumors. By utilizing advanced techniques like next-generation sequencing and QRT-PCR, the researchers aim to identify and characterize the dysregulated lncRNAs in leiomyomas, potentially uncovering new therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who have been diagnosed with uterine leiomyomas.
Not a fit: Patients who do not have uterine fibroids or are not of reproductive age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for women suffering from uterine fibroids, improving their quality of life.
How similar studies have performed: Previous research has shown promise in understanding the role of miRNAs in fibroid development, suggesting that exploring lncRNAs may yield valuable insights.
Where this research is happening
Torrance, United States
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, United States (Active)
Researchers
- Principal investigator: Khorram, Omid a. — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Khorram, Omid a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.