Understanding how long-lived bats manage genetic mutations
Patterns and Mechanisms Underlying Somatic Mutations Across Long-Lived Bats
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10949450
This study looks at how certain long-lived bats manage to stay healthy and age slowly by examining their genes, which could help us understand more about aging and how to prevent age-related diseases.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10949450 on ClinicalTrials.gov |
What this research studies
This research investigates the patterns and mechanisms of somatic mutations in long-lived bats to understand how these mutations relate to aging and longevity. By comparing genetic samples from various bat species with different lifespans, the study aims to uncover the genetic factors that contribute to their remarkable longevity. The approach involves advanced genomic techniques, including CRISPR, to analyze DNA damage repair responses in these animals. This research could provide insights into the biological processes that allow certain species to age more slowly and resist age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related conditions such as cancer, heart disease, or dementia.
Not a fit: Patients who are not interested in genetic research or do not have age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding aging and developing therapies for age-related diseases in humans.
How similar studies have performed: Previous studies have shown promising results in understanding longevity through comparative genomics, indicating that this approach has potential for success.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAZQUEZ, JUAN MANUEL — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: VAZQUEZ, JUAN MANUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.