Understanding how long immunity lasts after COVID-19 vaccination in patients with immune deficiencies
Mechanisms and Duration of Immunity to SARS-CoV-2
This study is looking at how well people with primary immune deficiency disorders respond to COVID-19 vaccines by checking their blood samples, so we can better understand their immune responses and improve vaccination strategies for those at higher risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10706724 on NIH RePORTER |
What this research studies
This research investigates the immune responses of patients with primary immune deficiency disorders (PID) to COVID-19 vaccinations. By analyzing blood samples from a cohort of 142 PID patients, the study aims to correlate genetic factors with immune responses, focusing on how well these patients can respond to vaccines. The research will utilize advanced techniques to characterize the types and frequencies of immune cells, as well as the specific antibodies produced after vaccination. This work is crucial for improving vaccination strategies for individuals at higher risk of severe COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary immune deficiency disorders, particularly those who have experienced suboptimal vaccine responses.
Not a fit: Patients without primary immune deficiency disorders or those who have not received COVID-19 vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and better health outcomes for patients with immune deficiencies.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in similar patient populations, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Boyd, Scott Dexter — Stanford University
- Study coordinator: Boyd, Scott Dexter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.