Understanding how long antibodies last after vaccination or infection
Antibody Durability Dynamics
This study is looking at how long the protection from COVID-19 vaccines lasts and why some vaccines work better than others, so we can find ways to help your body keep strong defenses against the virus for a longer time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10867310 on NIH RePORTER |
What this research studies
This research investigates the durability of antibody responses following vaccination or infection, particularly in the context of COVID-19. It aims to understand why some vaccines lead to long-lasting immunity while others do not, by examining the immune system's mechanisms and the types of vaccines used. The study will analyze how different immunological cues can be engineered to enhance the longevity of antibody responses, which is crucial for effective vaccination strategies. By exploring these dynamics, the research seeks to improve our understanding of how to elicit stable and protective antibody levels over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have received COVID-19 vaccinations or have had COVID-19 infections.
Not a fit: Patients who have not been vaccinated against COVID-19 or have not been infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of vaccines that provide longer-lasting immunity against infectious diseases.
How similar studies have performed: Other research has shown promising results in understanding antibody durability, particularly with vaccines like the HPV vaccine, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wesemann, Duane R. — Brigham and Women's Hospital
- Study coordinator: Wesemann, Duane R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.