Understanding how long-acting injectable medications work in the body
Official title: Development of PBPK Model-Based Mechanistic IVIVCs for Long-Acting Injectable Suspensions
Funded at University of Connecticut Storrs · NIH-11063656 · Data updated 2026-11-12
This study is looking at how different types of long-acting injectable medications work in your body after they're given, with the goal of making these treatments better and more predictable for people who need them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $300,000 |
| NIH project number | 1U01FD008304-01 |
| Project ID | NIH-11063656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals who require long-term medication management and could benefit from injectable therapies.
✕Less likely to help
Patients who do not require long-acting injectable medications or those who are not candidates for injectable therapies may not benefit from this research.
What this research studies
This research focuses on long-acting injectable (LAI) medications that are administered through injections and are designed to release drugs slowly over time. The study aims to explore how different formulation characteristics affect the way these medications behave in the body, particularly at the injection site. By using advanced modeling techniques, the researchers will investigate the relationship between the drug formulation and the physiological responses to improve the predictability of drug release. This could lead to better development of LAI medications, including generic versions, which are currently limited.
Why it matters
Potential benefit: If successful, this research could lead to improved long-acting injectable medications that are more effective and accessible for patients.
How similar studies have gone: While the approach of using physiologically based pharmacokinetic models is established, the specific application to long-acting injectable suspensions is relatively novel and underexplored.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Burgess, Diane Jane — University of Connecticut Storrs
- Study coordinator: Burgess, Diane Jane
Related research
Other NIH-funded projects on the same topics.
-
New sequencing machine to boost veterinary genomics at CVMDL
A new high-throughput DNA/RNA sequencer will be acquired and put into use at the Connecticut Veterinary Medical Diagnostic Laboratory to improve how we study and diagnose animal diseases.
-
How IL-10 changes mast cells in allergic reactions
This work looks at how the immune signal IL-10 changes mast cells and their responses in people with food allergies.
-
Optimizing a just-in-time intervention to help MSM access chemsex harm-reduction services
A smartphone app-driven approach tests personalized, timely support to help men who have sex with men access chemsex harm-reduction services and reduce HIV risk.
-
Understanding how vagus nerve stimulation helps stroke recovery to guide better treatments
This NIH grant uses computer models to figure out how brief, task-timed vagus nerve stimulation affects the brain after stroke and helps movement recovery.
-
Targeting c-Myc DNA with next-generation nucleic acid tools in aggressive B-cell lymphomas
This grant tests a new way to slow or stop aggressive B-cell lymphomas by directly targeting the c-Myc gene in patients and model systems using advanced nucleic acid analogs.
-
Soft, bendable 3D electronics and microfluidic micro-labs for drug screening in engineered tissues
A team at the University of Connecticut is building a soft, 3D electronic and microfluidic platform to grow human organoids and test drugs safely and accurately.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.