Understanding how long-acting injectable medications work in the body
Development of PBPK Model-Based Mechanistic IVIVCs for Long-Acting Injectable Suspensions
['FUNDING_U01'] · UNIVERSITY OF CONNECTICUT STORRS · NIH-11063656
This study is looking at how different types of long-acting injectable medications work in your body after they're given, with the goal of making these treatments better and more predictable for people who need them.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT STORRS (nih funded) |
| Locations | 1 site (STORRS-MANSFIELD, UNITED STATES) |
| Trial ID | NIH-11063656 on ClinicalTrials.gov |
What this research studies
This research focuses on long-acting injectable (LAI) medications that are administered through injections and are designed to release drugs slowly over time. The study aims to explore how different formulation characteristics affect the way these medications behave in the body, particularly at the injection site. By using advanced modeling techniques, the researchers will investigate the relationship between the drug formulation and the physiological responses to improve the predictability of drug release. This could lead to better development of LAI medications, including generic versions, which are currently limited.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals who require long-term medication management and could benefit from injectable therapies.
Not a fit: Patients who do not require long-acting injectable medications or those who are not candidates for injectable therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved long-acting injectable medications that are more effective and accessible for patients.
How similar studies have performed: While the approach of using physiologically based pharmacokinetic models is established, the specific application to long-acting injectable suspensions is relatively novel and underexplored.
Where this research is happening
STORRS-MANSFIELD, UNITED STATES
- UNIVERSITY OF CONNECTICUT STORRS — STORRS-MANSFIELD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURGESS, DIANE JANE — UNIVERSITY OF CONNECTICUT STORRS
- Study coordinator: BURGESS, DIANE JANE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.