Understanding how local skin factors affect repigmentation in vitiligo
Determining how local factors influence repigmentation in stable vitiligo
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11097219
This study is looking into why some spots on the skin regain color after treatment for vitiligo while others don’t, and it’s for people with vitiligo who want to understand how their skin can respond better to therapies.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11097219 on ClinicalTrials.gov |
What this research studies
This research investigates the autoimmune skin condition vitiligo, which leads to the loss of skin color due to the destruction of melanocytes by T cells. The study aims to understand why some areas of skin repigment while others do not after treatment with narrow band ultraviolet B therapy and topical steroids. By using advanced imaging techniques and genetic analysis, researchers will explore the role of specific skin cells, termed 'stress keratinocytes', in influencing the repigmentation process. The goal is to identify local signals that could improve treatment outcomes for patients with vitiligo.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with stable vitiligo who are undergoing or have undergone treatment.
Not a fit: Patients with vitiligo who are not receiving treatment or those with other skin conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for vitiligo, resulting in improved skin repigmentation and reduced psychological distress for patients.
How similar studies have performed: Previous research has shown promise in understanding the mechanisms of vitiligo, but this specific approach using advanced imaging and genetic techniques is relatively novel.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIU, JESSICA — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SHIU, JESSICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.