Understanding how liver T cells respond to hepacivirus infections
New insights into the functional diversity of the hepatic antiviral T cell response during hepacivirus infection in vivo
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11086074
This study is looking at how different T cells in the liver help fight off infections from a virus similar to hepatitis C, using a special mouse model to understand their role better, which could eventually lead to improved treatments and vaccines for people with liver diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11086074 on ClinicalTrials.gov |
What this research studies
This research investigates the role of different types of T cells in the liver during infections caused by hepacivirus, which is related to hepatitis C virus. By using a newly developed mouse model that mimics human liver infections, the study aims to uncover how these T cells contribute to fighting the virus and how they might also cause liver damage. The findings could lead to better vaccine strategies and immunotherapies for liver diseases. Patients may benefit from insights that could improve treatment options for chronic liver infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic hepatitis C virus infections or related liver diseases.
Not a fit: Patients with liver diseases not related to viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and therapies for patients suffering from liver diseases related to viral infections.
How similar studies have performed: Other research has shown success in understanding T cell responses in viral infections, making this approach promising but still innovative in the context of hepacivirus.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BILLERBECK, EVA — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: BILLERBECK, EVA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection