Understanding how liver metabolism is controlled in health and disease
The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolism
This study looks at how two proteins in the liver work together to control metabolism, which could help us understand and find new treatments for conditions like low blood sugar and fatty liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11091448 on NIH RePORTER |
What this research studies
This research investigates the interaction between two important proteins, NRF2 and FBP1, that regulate liver metabolism. By studying genetically modified mice, the researchers aim to understand how these proteins influence metabolic processes such as gluconeogenesis and the body's response to insulin. The study focuses on how NRF2 can affect the degradation of FBP1 and how this relationship impacts conditions like hypoglycemia and fatty liver disease. Patients may benefit from insights gained about liver metabolism and potential new treatments for metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children under 11 years old with metabolic disorders related to liver function.
Not a fit: Patients with metabolic conditions unrelated to liver function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing liver-related metabolic diseases in patients.
How similar studies have performed: Other research has shown promising results in understanding metabolic regulation through similar biochemical pathways, suggesting potential for success in this area.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Karin, Michael — University of California, San Diego
- Study coordinator: Karin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.