Understanding how liver injuries lead to liver cancer
Tumor-promoting liver injuries and mechanisms
This study is looking at how different liver problems can lead to liver cancer, and it's for anyone interested in understanding how changes in liver cells might help tumors grow, with the hope of finding better treatments for liver cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10799557 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which various liver injuries and disorders contribute to the development of hepatocellular carcinoma (HCC), a major cause of cancer-related deaths. The team focuses on how the loss of certain molecules in liver cells can ironically promote tumor growth. By using mouse models that mimic human liver cancer, the researchers aim to uncover the cellular and molecular events that drive cancer progression. This comprehensive analysis could reveal shared mechanisms between animal models and human patients, potentially leading to new insights in liver cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver disorders or those at high risk for developing hepatocellular carcinoma.
Not a fit: Patients with liver cancer who are already in advanced stages may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with liver cancer.
How similar studies have performed: Other research has shown success in understanding liver cancer mechanisms, but this specific approach is exploring novel aspects of tumor promotion.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Feng, Gen-Sheng — University of California, San Diego
- Study coordinator: Feng, Gen-Sheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.