Understanding how liver inflammation affects brain health as we age
The role of hepatocyte necroptosis and inflammation in liver-brain crosstalk in aging
This project explores how inflammation in the liver, a common issue with aging, might contribute to memory and thinking problems in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11131154 on NIH RePORTER |
What this research studies
As we get older, our bodies often experience low-level inflammation, which can affect various organs, including the liver. This inflammation in the liver, known as liver aging, is linked to chronic liver diseases and is thought to play a role in brain inflammation and memory issues. Researchers are looking into a specific cell death process called necroptosis, which releases inflammatory signals and appears to increase in the liver with age. By understanding how this liver process contributes to inflammation and how it might connect to brain health, we hope to uncover new ways to protect our minds as we age.
Who could benefit from this research
Good fit: This research is relevant for adults aged 21 and older who are interested in the biological processes of aging, particularly those concerning liver health and cognitive function.
Not a fit: Patients seeking immediate treatment for existing conditions may not directly benefit from this foundational biological research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat age-related memory and thinking problems by targeting liver health.
How similar studies have performed: While the specific link between liver necroptosis and human cognitive decline is still being uncovered, previous findings in animal models suggest that targeting necroptosis can reduce inflammation and improve liver health.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Sathyaseelan, Deepa — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Sathyaseelan, Deepa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.