Understanding how liver inflammation affects alcohol consumption and liver disease
Identifying an immunoregulatory axis for FGF21 in alcohol consumption
This study is looking at how liver inflammation affects how your body processes alcohol and aims to find new ways to help people with alcohol use issues by focusing on a protein called FGF21.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11048195 on NIH RePORTER |
What this research studies
This research investigates the relationship between liver inflammation and alcohol consumption, particularly focusing on a protein called FGF21 that is influenced by liver conditions. The study aims to uncover how inflammation in the liver can alter the metabolism of alcohol and contribute to alcohol-related liver diseases. By examining the interactions between specific immune and metabolic pathways, the researchers hope to identify new treatment strategies for individuals struggling with alcohol use disorder. Patients may be involved in clinical trials that explore these mechanisms and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with alcohol use disorder or those experiencing liver complications related to alcohol consumption.
Not a fit: Patients who do not consume alcohol or have no history of alcohol-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help reduce alcohol consumption and improve outcomes for patients with alcohol-related liver diseases.
How similar studies have performed: Previous research has shown promising results in understanding the metabolic effects of liver inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Patel, Suraj J — Ut Southwestern Medical Center
- Study coordinator: Patel, Suraj J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.