Understanding how liver immune cells affect HIV persistence during treatment
Defining a Role for Liver Myeloid Cells in Viral Persistence under ART
This study is looking at how certain immune cells in the liver might help the HIV virus stick around even when people are on treatment, and by understanding this better, researchers hope to find new ways to help people with HIV live healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11086623 on NIH RePORTER |
What this research studies
This research investigates the role of liver myeloid cells, specifically Kupffer cells, in the persistence of HIV-1 despite antiretroviral therapy (ART). The study aims to identify how these immune cells may harbor the virus and contribute to its resilience against treatment. By analyzing the characteristics of viral particles derived from these cells, researchers hope to uncover new strategies for eliminating viral reservoirs. This could lead to more effective approaches for achieving remission or a cure for HIV-1 infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have experienced viral persistence.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in HIV treatment, potentially allowing for a functional cure or improved management of the virus.
How similar studies have performed: Previous research has shown promise in understanding viral reservoirs in other immune cell types, but this specific focus on liver myeloid cells is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Stevenson, Mario — University of Miami School of Medicine
- Study coordinator: Stevenson, Mario
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.