Understanding how liver cells produce certain lipoproteins linked to heart disease
Official title: Novel regulatory mechanisms controlling hepatic apoB-Lp lipid loading and secretion
Funded at NYU Long Island School of Medicine · NIH-11064056 · Data updated 2026-11-12
This study is looking at how liver cells make certain fats that can lead to heart problems, especially by checking how fat levels and protein breakdown affect this process, and it’s for anyone interested in understanding more about heart health and potential new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $422,764 |
| NIH project number | 5P01HL160470-03 |
| Project ID | NIH-11064056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerotic cardiovascular disease, particularly those with metabolic disorders affecting lipid metabolism.
✕Less likely to help
Patients who do not have metabolic disorders or cardiovascular disease may not benefit from this research.
What this research studies
This research investigates the mechanisms by which liver cells generate atherogenic lipoproteins, particularly focusing on the role of lipid levels and protein degradation in this process. It examines how interactions between adipose tissue and liver influence the production of these lipoproteins, which are associated with cardiovascular diseases. The study employs advanced molecular techniques to explore how the body regulates the assembly and secretion of these lipoproteins under varying lipid conditions. By understanding these processes, the research aims to identify potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerotic cardiovascular diseases.
How similar studies have gone: Previous research has shown success in understanding lipid metabolism and its implications for cardiovascular health, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Fisher, Edward a — NYU Long Island School of Medicine
- Study coordinator: Fisher, Edward a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.