Understanding how liver cells help the liver heal
Official title: Molecular Determinants of liver sinusoidal endothelial cells for hepatic regeneration
Funded at Weill Medical Coll of Cornell Univ · NIH-11085155 · Data updated 2026-11-12
This study is looking at how certain cells in the liver help it heal without causing scars, and it aims to find new ways to improve liver recovery for people with liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $451,664 |
| NIH project number | 5R01DK136327-03 |
| Project ID | NIH-11085155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from end-stage liver disease or conditions that impair liver regeneration.
✕Less likely to help
Patients with liver diseases that are not related to the dysfunction of liver sinusoidal endothelial cells may not benefit from this research.
What this research studies
This research investigates the specialized functions of liver sinusoidal endothelial cells (LSECs) that are crucial for liver regeneration. By exploring the molecular mechanisms that enable these cells to support liver repair without scarring, the study aims to identify potential therapeutic targets. The researchers will utilize advanced techniques to manipulate specific transcription factors in LSECs, which may enhance their regenerative capabilities. Patients with liver disease may benefit from insights gained through this research, potentially leading to new treatments that promote liver healing.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enable scar-free liver regeneration for patients with liver disease.
How similar studies have gone: Previous research has shown promising results in understanding liver cell functions, indicating that this approach has potential for success.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Rafii, Shahin — Weill Medical Coll of Cornell Univ
- Study coordinator: Rafii, Shahin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.