Understanding how liver cells grow under stress
A new mechanism of hepatocyte proliferation under stress
This study is looking at how liver cells can still grow and heal even when they're under stress, focusing on a protein called Shp2 that helps them communicate; understanding this could lead to new treatments for liver diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10791822 on NIH RePORTER |
What this research studies
This research investigates how liver cells, known as hepatocytes, can still grow and regenerate even when they face stress or damage. The team is focusing on a specific protein called Shp2, which plays a role in cell signaling. By studying liver cells that lack Shp2, they aim to uncover how these cells communicate and form clusters to promote their growth despite challenges. This could provide insights into liver regeneration processes and potential therapeutic targets for liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver conditions or those who have experienced liver damage.
Not a fit: Patients with healthy liver function or those without any liver-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance liver regeneration in patients with liver damage or disease.
How similar studies have performed: Other research has shown promising results in understanding liver regeneration mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Feng, Gen-Sheng — University of California, San Diego
- Study coordinator: Feng, Gen-Sheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.