Understanding how liver cells develop and function
Molecular regulation of hepatic cell differentiation and maturation
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10456054
This study is looking at how a protein called Znhit1 helps liver cells grow and change from their early stages to fully developed cells, which could lead to better treatments for liver diseases in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10456054 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that govern the differentiation and maturation of liver cells, focusing on a specific protein called Znhit1. By using mouse models, the researchers aim to understand how Znhit1 influences liver cell function and gene expression during development. The study seeks to uncover the role of Znhit1 in regulating the transition of liver cells from embryonic to adult forms, which is crucial for maintaining normal liver function. Patients may benefit from insights gained into liver cell development, which could inform future therapies for liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults with liver conditions or those interested in liver health.
Not a fit: Patients with acute liver failure or those requiring immediate clinical interventions may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating liver diseases by enhancing our understanding of liver cell development.
How similar studies have performed: Other research has shown success in understanding cellular differentiation processes, making this approach promising yet still exploratory.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUPPERT, STACEY S — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: HUPPERT, STACEY S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.