Understanding how liver cells contribute to liver cancer development
Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer
This study is looking at how certain cells in the liver might help liver cancer grow, with the hope that understanding this could lead to better treatments for patients with liver cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11001123 on NIH RePORTER |
What this research studies
This research investigates the role of hepatic stellate cells in the development of liver cancer, specifically hepatocellular carcinoma (HCC). It focuses on the molecular mechanisms that govern how these cells interact with the tumor microenvironment and contribute to cancer progression. By examining the effects of specific proteins and cellular processes, the study aims to uncover new insights into liver cancer biology that could lead to improved treatments. Patients may benefit from findings that enhance our understanding of liver cancer and its treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hepatocellular carcinoma or those at high risk for developing liver cancer.
Not a fit: Patients with liver cancer unrelated to the mechanisms being studied or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for liver cancer that improve patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding the role of cellular mechanisms in cancer progression, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Moscat, Jorge — Weill Medical Coll of Cornell Univ
- Study coordinator: Moscat, Jorge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.