Understanding how liver cell growth affects cell division
Determining the mechanisms linking cell growth to the cell cycle in the liver
This study looks at how liver cells grow and divide, especially focusing on how bigger cells handle their DNA and other parts, using mouse liver cells to learn more about these processes, which could help improve treatments for liver diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10813137 on NIH RePORTER |
What this research studies
This research investigates the relationship between cell growth and the cell cycle in liver cells, specifically focusing on how larger cells manage their DNA and cytoplasm ratios. By studying mouse liver cells, the research aims to uncover the molecular mechanisms that link cell size to DNA replication and division. The approach involves examining how certain proteins regulate these processes during development and regeneration. Patients may benefit from insights gained about liver cell behavior, which could inform treatments for liver-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with liver diseases or conditions that affect cell growth and division.
Not a fit: Patients with conditions unrelated to liver function or cell growth mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating liver diseases and cancers by targeting the mechanisms of cell growth and division.
How similar studies have performed: Other research has shown success in understanding cell cycle regulation, but this specific approach to linking cell growth and DNA replication in liver cells is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Skotheim, Jan M — Stanford University
- Study coordinator: Skotheim, Jan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.