Understanding how liver cancer develops through specific signaling pathways
Signaling pathways during hepatocarcinogenesis
This study is looking at how certain proteins in the body affect the growth of liver cancer, hoping to find new ways to treat it that could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-10775793 on NIH RePORTER |
What this research studies
This research investigates the complex signaling pathways involved in the development of hepatocellular carcinoma (HCC), a serious type of liver cancer. The study focuses on the roles of two protein complexes, mTORC1 and mTORC2, in regulating cell growth and metabolism, particularly how they interact with key proteins that may influence cancer progression. By using mouse models, researchers aim to uncover how these pathways contribute to liver tumor formation and identify potential targets for new treatments. Patients may benefit from insights gained that could lead to improved therapies for HCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hepatocellular carcinoma or those at high risk for developing liver cancer.
Not a fit: Patients with other types of cancer or those without liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients with hepatocellular carcinoma.
How similar studies have performed: Previous research has shown promising results in understanding signaling pathways in various cancers, suggesting that this approach could yield valuable insights for hepatocellular carcinoma as well.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Chen, Xin — University of Hawaii at Manoa
- Study coordinator: Chen, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.