Understanding how liver aging affects cancer development
Hepatic Tissue Integrity and Clonal Fitness: Key Factors in Controlling β-Catenin Induced Oncogenesis
['FUNDING_R01'] · RESEARCH INST OF FOX CHASE CAN CTR · NIH-11042212
This study is looking at how the health of liver tissue changes as we age and how that might affect the risk of developing liver cancer, especially in people with chronic liver disease, so we can better understand the connection between aging and cancer risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RESEARCH INST OF FOX CHASE CAN CTR (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11042212 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between liver tissue integrity and the development of cancer, particularly focusing on how aging influences this process. By studying mouse models, the researchers aim to understand why certain mutations in liver cells can lead to cancer over time, despite being present for years without causing disease. The study will explore how chronic liver disease may accelerate aging in the liver, potentially leading to an increased risk of hepatocellular carcinoma. Patients may benefit from insights into how aging impacts cancer risk and the underlying mechanisms involved.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with chronic liver disease or those at risk for liver cancer.
Not a fit: Patients without liver disease or those who are not of advanced age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing liver cancer in older adults.
How similar studies have performed: Previous research has shown that understanding the aging process in tissues can provide valuable insights into cancer development, suggesting that this approach may yield significant findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- RESEARCH INST OF FOX CHASE CAN CTR — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FONT-BURGADA, JOAN — RESEARCH INST OF FOX CHASE CAN CTR
- Study coordinator: FONT-BURGADA, JOAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: aging associated disease, aging associated disorders, aging related disease